How to isolate systemic hangs in macOS 10.14?

I'm struggling with some kind of a hang that is very elusive. Apple can't seem to isolate the problem after many sysdiagnose submissions. It predominantly happens in instances of Google Chrome, Finder and even Activity Monitor (and other random apps) sometimes when certain actions are taken. The only way to recover is a sudo reboot from the shell. No drives are actually failed or failing as one might expect. This is on a Mac Pro with ECC memory and all RAM is showing as good. I have to think that there's some dtrace tooling that would facilitate tracking down the precise point of the hang. It feels as though it's some form IO failure, but there's no indication of where or how... What options exist for tracking down such issues at a very low level?