Apps broken after Monterey 12.3 update

After having updated macOS to Monterey 12.3 a number of programs or apps are failing to work. For example, when trying to run perl I obtain

-bash: /usr/local/bin/perl: Bad CPU type in executable

Same thing when trying to run python:

-bash: /Users/myusername/opt/anaconda3/bin/python: Bad CPU type in executable

A number of Apps downloaded from the Mac App Store also do not work and return a laconic "Unable to check for updates, please check your internet connection and try again" window (I am, of course, connected to the internet). Thinking that this problem might be related to Rosetta I have tried updating,

softwareupdate --install-rosetta

to no avail. I got the following as a response

Rosetta 2 update is not available

All help appreciated!