How do I run iOS apps on macOS with Permissive Security enabled?

I use a legacy driver called HoRNDIS, which allows me to tether my Android phone's mobile connection over USB. However, because it doesn't use DriverKit, I have to set the Startup Security of macOS to 'Permissive'. However, I want to run an iOS application, but when I run the app, I get an error:

open this app, you’ll need to start up your Mac from macOS Recovery and change the Security Policy to Full Security or Reduced Security.

Is there a way I can run the app and have Permissive Security at the same time?