Queries return ReadFailure exception, "Replica(s) failed to execute read"

I've a cluster consisting of 5 cassandra nodes. The cassandra version used is cassandra-3.11.3-1.noarch The keyspace strategy and is defined as follows: CREATE KEYSPACE my_keyspace WITH replication = {'class': 'NetworkTopologyStrategy', 'datacenter1': '2'} AND durable_writes = true; Now running queries on the cluster, the following issue occurs: > ReadFailure: Error from server: code=1300 [Replica(s) failed to execute read] > message="Operation failed - received 0 responses and 1 failures" > info={'consistency': 'LOCAL_ONE', 'received_responses': 0, 'required_responses': 1, 'failures': 1} > info={'failures': None, 'consistency': 'Not Set', 'required_responses': None, 'received_responses': None} Does anyone know what is causing this? If more information needed to better debug this problem, please let me know! **UPDATE 1** root# awk '!/#/' /etc/cassandra/conf/cassandra-rackdc.properties dc=datacenter1 rack=rack1