How large should be mysql innodb_buffer_pool_size?

I have a busy database with solely InnoDB tables which is about 5GB in size. The database runs on a Debian server using SSD disks and I've set max connections = 800 which sometimes saturate and grind the server to halt. The average query per second is about 2.5K. So I need to optimize memory usage to make room for maximum possible connections. I've seen suggestions that innodb_buffer_pool_size should be up to %80 of the total memory. On the other hand I get this warning from tuning-primer script: Max Memory Ever Allocated : 91.97 G Configured Max Per-thread Buffers : 72.02 G Configured Max Global Buffers : 19.86 G Configured Max Memory Limit : 91.88 G Physical Memory : 94.58 G Here are my current innodb variables: | innodb_adaptive_flushing | ON | | innodb_adaptive_hash_index | ON | | innodb_additional_mem_pool_size | 20971520 | | innodb_autoextend_increment | 8 | | innodb_autoinc_lock_mode | 1 | | innodb_buffer_pool_instances | 1 | | innodb_buffer_pool_size | 20971520000 | | innodb_change_buffering | all | | innodb_checksums | ON | | innodb_commit_concurrency | 0 | | innodb_concurrency_tickets | 500 | | innodb_data_file_path | ibdata1:10M:autoextend | | innodb_data_home_dir | | | innodb_doublewrite | ON | | innodb_fast_shutdown | 1 | | innodb_file_format | Antelope | | innodb_file_format_check | ON | | innodb_file_format_max | Antelope | | innodb_file_per_table | ON | | innodb_flush_log_at_trx_commit | 2 | | innodb_flush_method | O_DIRECT | | innodb_force_load_corrupted | OFF | | innodb_force_recovery | 0 | | innodb_io_capacity | 200 | | innodb_large_prefix | OFF | | innodb_lock_wait_timeout | 50 | | innodb_locks_unsafe_for_binlog | OFF | | innodb_log_buffer_size | 4194304 | | innodb_log_file_size | 524288000 | | innodb_log_files_in_group | 2 | | innodb_log_group_home_dir | ./ | | innodb_max_dirty_pages_pct | 75 | | innodb_max_purge_lag | 0 | | innodb_mirrored_log_groups | 1 | | innodb_old_blocks_pct | 37 | | innodb_old_blocks_time | 0 | | innodb_open_files | 300 | | innodb_purge_batch_size | 20 | | innodb_purge_threads | 0 | | innodb_random_read_ahead | OFF | | innodb_read_ahead_threshold | 56 | | innodb_read_io_threads | 4 | | innodb_replication_delay | 0 | | innodb_rollback_on_timeout | OFF | | innodb_rollback_segments | 128 | | innodb_spin_wait_delay | 6 | | innodb_stats_method | nulls_equal | | innodb_stats_on_metadata | ON | | innodb_stats_sample_pages | 8 | | innodb_strict_mode | OFF | | innodb_support_xa | ON | | innodb_sync_spin_loops | 30 | | innodb_table_locks | ON | | innodb_thread_concurrency | 4 | | innodb_thread_sleep_delay | 10000 | | innodb_use_native_aio | ON | | innodb_use_sys_malloc | ON | | innodb_version | 1.1.8 | | innodb_write_io_threads | 4 | A side note that might be relevant: I see that when I try to insert a large post (say over 10KB) from Drupal (which sits on a separate web server) to database, it lasts forever and the page does not return correctly. Regarding these, I'm wondering what should be my innodb_buffer_pool_size for optimal performance. I appreciate your suggestions to set this and other parameters optimally for this scenario.