Upgrade Aurora from 5.6 to 5.7.mysql_aurora.2.11.1 getting tons of deadlocks and lock wait timeouts, maybe 20-30x what they were before the upgrade

Our application logs are showing an excessive amount of lock wait times, and deadlocks for queries that have not had issues previously after upgrading from 5.6 to 5.7 MySQL in AWS Aurora. Are there any settings that I can adjust to reduce the deadlocks and lock wait timeouts? Variables and settings here: https://pastebin.com/cmu11Dwh Running on db.r5.12xlarge