Are harmless sp_configure commands always safe to run?

Suppose that I wish to run the following

/* Check for any pending configurations, just in case. */
SELECT *
FROM sys.configurations
WHERE value  value_in_use;
GO
 
EXEC sp_configure 'remote admin connections', 1;
GO
RECONFIGURE
GO

Is there any risk, such as clearing the plan cache or blocking queries, to running this during a busy day? I know that the remote admin connection is safe. I'm concerned about sp_configure.