MySQL / Fusion IO Configuration Question

I need a little configuration optimization. I think what I have is pretty good but feel like there's still room for improvement. **Current Config** [mysqld] user=mysql datadir=/var/lib/mysql socket=/var/lib/mysql/mysql.sock #innodb innodb_log_file_size = 256M innodb_log_buffer_size = 32M innodb_read_io_threads=8 innodb_write_io_threads=8 innodb_flush_log_at_trx_commit = 2 innodb_lock_wait_timeout=50 innodb_file_per_table innodb_buffer_pool_size=16G innodb_buffer_pool_instances=8 innodb_io_capacity=10000 #eliminating double buffering innodb_flush_method = O_DIRECT flush_time=86400 # Disabling symbolic-links is recommended to prevent assorted security risks; # to do so, uncomment this line: # symbolic-links=0 #tmpdir=/dev/shm #tmpdir=/usr/tmpfs skip-name-resolve #skip-locking #safe-show-database query_cache_limit=4M query_cache_size=256M sort_buffer_size=8M read_rnd_buffer_size=1M max_connections=5000 interactive_timeout=60 wait_timeout=300 connect_timeout=30 thread_cache_size=32 key_buffer=124M tmp_table_size=4096M max_heap_table_size=256M join_buffer=16M max_connect_errors=2000 table_cache=2048 thread_concurrency=12 long_query_time=5 log-slow-queries=/var/log/mysql-slow.log #table_definition_cache=384 max_allowed_packet=1024M #server-id=20 #log-bin=mysql-bin #expire_logs_days=10 event_scheduler=ON #master-host = #master-user = #master-password = #master-port = 3306 [mysqld_safe] log-error=/var/log/mysqld.log pid-file=/var/run/mysqld/mysqld.pid **Dedicated Database server specs** - VMWare VM - Dual Quad Xeon X5680 @ 3.33GHz (8 vCPU) - 24gb RAM - Fusion IO mounted on /var/lib/mysql - Rough total of 500 tables between all databases I know this kind of question really kind of requires eyes on the database server but I will gladly append information to this question as needed in order to get a much better configuration. Thanks for the help in advance.