apache mod_security and performance

I have a list of bots to block, so I was thinking that fail2ban could be a solution until I realized that mod_security would be more efficient in this kind of tasks. The number of bots is huge, so the file of configuration will contain a long list. My question is about performance (memory, processor, disk ..etc): Is having a huge list of bots to block will affect the performance of apache in a site with huge traffic ?