UUID's when changing hardware

In /etc/sysconfig/network-scripts/ifcfg-eno1 there is a UUID to identify the on-board network interface. I also notice now that some partitions in fstab are also identified by a UUID. If I remove the hard drives from this server and put them into a new "identical" server, will everything still work as expected? I doubt there would be an issue with the HDD's, as the UUID's will move with them, but will there be some sort of mismatch on the network UUIDs, as the hardware has changed? It stands to reason that if I have a faulty system board, I will want to move the storage into a spare server and have everything working again quickly. Are the network interface UUID's only used by Network Manager? I have that disabled, so perhaps it's a good idea to simply remove the UUID entry from the config file anyway.