Preventative Maintenance on OS X / Running Onyx unattended

We have a Business Unit that has about 20 Mac's. From time to time, when we need to solve strange issues that are not configuration issues. I will often run "Onyx", and unless there is an underlying hardware issue, it usually solves the problem. I run the Automation, and have it rebuild just about all the caches. Is there a best practice for preventing these cache issues from time to time, or a way to automate purging them to prevent issues in the first place? The Business Unit manager would like to not have to open a support ticket with us, if this can be prevented by routine maintenance.