OpenBSD patch system

If I install OpenBSD from CD-ROM: http://www.openbsd.org/ftp.html with install48.iso then is it patched? 1. All 10 patches from here are in the ISO file? 2. If those are not included, how can I apply these patches? Is there a one-liner command (like under Fedora: yum upgrade or Debian based, apt-get upgrade) or do I have to download and apply all 10 patches one by one?