Does X11 support mice with Z axis (ie relative motion events with 3 axes), & possibly relative rotations too, ie 6DOF? If so, do Tk/Gtk/Qt?

From all the .conf files used to configure XInput, it seems X11 innately does not support a Z axis, let alone relative rotations. Is this correct? How are trackballs supported, if at all? Are spacemice supported? If so, how? Does this carry over to Tk/Gtk/Qt hence target apps using those frameworks?