Should I remove i386 packages?

I am on Linux Mint 21.2 (Victoria) Cinnamon amd64 on Intel 7700HQ, and since I now found out there are 293 (dpkg -l | grep i386 | wc -l) 32-bit (i386) packages left from previous years, I don't know if this question is clear, but anyway: Should I remove all i386 packages? If so, or at least the majority of them, how should I proceed in several manageable steps? Thank you.