Run a script when Clipboard is changed

I know that the clipboard is not a function of the Linux kernel but a feature of the desktop. And there is no "location" where the content in the clipboard is saved. Clipboard is saved in RAM. Is there a way to run a script every time the clipboard is changed? The only way I know is to run a infinite loop, something like this: while true; do var1=$(xclip -selection clipboard -o) sleep 0.5 var2=$(xclip -selection clipboard -o) if [ "$var1" != "$var2" ]; then make crazy sh*t fi done Is this the only way?