What's the best way to use SuperDuper to back up multiple hard drives to partitions on a single drive?

Here's the setup I'm setting up: - Mac HD (500GB SSD) - Media HD (2TB SSD) - Daily Backup HD (3TB HDD, partitioned into a 2TB Daily Backup Mac HD, a 500GB Daily Backup Media HD, and an irrelevant 500GB Spare HD) - Time Machine HD, (4TB, but this drive isn't relevant for my question). Using SuperDuper, what's the proper way to back up two separate drives to partitions on a single external drive? Can I back up my Mac HD and my Media HD at the same time? It'll be running automatically in the middle of the night, so speed isn't a concern. I've been backing up one drive M/W/F and the other T/T/S, but I'd like to switch to backing both drives up daily. With SuperDuper, can I schedule both to run at the same time? Also: Since my Mac and Media drives are SSD but my backup drive is a partitioned HDD, is there anything I should be careful of when I format the backup drive? EDIT: I'm specifically asking about backing up multiple hard drives to separate partitions on a single drive. I already have an external 3TB drive partitioned for backups. If my Mac hard drive dies, I like having a bootable backup ready to go in an instant without needing to restore it first. If my Media drive dies, I like having a backup ready to go without needing to restore it first. I also have another external drive for Time Machine. I'm religious about backing everything up (safety first, as they say). I just want to make sure it's fine to back up two hard drives to two partitions on a single drive at the same time.